Active and Passive Immunization with rHyr1p-N Protects Mice against Hematogenously Disseminated Candidiasis
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Active and Passive Immunization with rHyr1p-N Protects Mice against Hematogenously Disseminated Candidiasis
We previously reported that Candida albicans cell surface protein Hyr1 encodes a phagocyte killing resistance factor and active vaccination with a recombinant N-terminus of Hyr1 protein (rHyr1p-N), significantly protects immunocompetent mice from disseminated candidiasis. Here we report the marked efficacy of rHyr1p-N vaccine on improving the survival and reducing the fungal burden of dissemina...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2011
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0025909